• br User knowledge representation Various representation appr

  2020-05-18

  

  User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The

• br Materials and methods br

  2020-05-16

  

  Materials and methods Results Discussion Natural compounds and their derivatives have been investigated as candidates for the treatment of bone diseases and can also be the sources of nutraceutical agents and therapeutic agents [28]. Using peptides as therapeutic effects on bone-related dis

• Db model cells showed various

  2020-05-16

  

  Db model cells showed various aberrant phenotypes that seemed to reflect the pathological abnormalities found under diabetic conditions. First, in Db model cells after insulin stimulation, we found the inhibition of the transcriptional repression of the gluconeogenic genes, PCK1 and G6PC, and aberra

• The lungs dissected from week mice

  2020-05-16

  

  The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco\'s modified Eagle\'s medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37

• br Materials and methods br Results br

  2020-05-15

  

  Materials and methods Results Discussion In rodent species, CYP2E1 and CYP2B have been implicated in CCl4 metabolism. In this study, we used expressed human CYP2E1 to show that this enzyme is a high-affinity catalyst responsible for low-dose CCl4 metabolism. Studies employing an inhibitory

• Cyclosporine NEORAL Oral Solution Novartis

  2020-05-15

  

  Cyclosporine (NEORAL® Oral Solution, Novartis) is an immunosuppressant widely used in organ transplantation and many other clinical conditions [12]. It undergoes extensive hepatic and intestinal biotransformation mainly via the metabolizing enzyme, CYP3A4 [[12], [13], [14], [15]]. Considering the na

• Tirofiban The purpose of this study is

  2020-05-15

  

  The purpose of this study is to investigate KDM1B expression and its functional significance in PC. We used lentivirus-mediated shRNA to down-regulate KDM1B expression in PC cell lines in vitro and detected the changes of cell proliferation and apoptosis. These studies provided a novel insight into

• While apparent that His Artemis fractionated over

  2020-05-15

  

  While apparent that [His]6-Artemis fractionated over a HAP column is devoid of 5′–3′ exonuclease activity but still retains DNA-PK dependent hairpin-opening activity, we sought to further assess DNA-PK dependent Artemis overhang cleavage activity to ensure all the in vivo, intrinsic enzymatic activi

• Most data regarding fish CXCR functions

  2020-05-15

  

  Most data regarding fish CXCR4 functions have accumulated from work in zebrafish where a range of genetic tools and imaging technologies have been developed. As mentioned above, in teleost fish the two CXCR4s (CXCR4a and 4b) are assumed to interact with two ligands (CXCL12a and 12b) and this differe

• LY83583 With a favorable spectrum of CRTh dependent in vitro

  2020-05-15

  

  With a favorable spectrum of CRTh2 dependent in vitro and in vivo efficacy demonstrated, the off-target activity of compound 18 was investigated, first against a panel of prostanoid receptors and related eicosanoid targets (Table 8), where no significant activities at 10μM concentration were found i

• Lipolysis and fatty acid oxidation are two important mechani

  2020-05-15

  

  Lipolysis and fatty cmv oxidation are two important mechanisms involved in fat reduction. Over stimulation of lipolysis increases the level of FFAs in the serum and causes metabolic perturbation (Koutsari and Jensen, 2006). A large inflow of FFAs to the mitochondria may lead to mitochondrial membra

• The interest for lanthanide and actinide complexes

  2020-05-15

  

  The interest for lanthanide and actinide complexes appeared again recently, due to their unique features in the design of Single Molecule Magnets (SMM). Lanthanide SMMs are interesting due to large their intrinsic magnetic anisotropy, but their core 4f orbitals minimally participate in exchange inte

• Although the presence of at

  2020-05-15

  

  Although the presence of at least one triple helix domain is typically the collagen signature, collagens are modular proteins composed of a succession of collagenous (COL) and non-collagenous domains (NC) that are both involved in collagen functions and in receptor binding. COL domains are linked by

• Acknowledgments The authors thank Dr Vladimir Poltoratsky an

  2020-05-15

  

  Acknowledgments The authors thank Dr. Vladimir Poltoratsky and Zhihui Xiao for their help with the in vitro FRET assay. Support for this research was provided by Saint John’s University. Introduction We predicted the existence of endothelium-derived contractile factors (EDCFs) in 1982 [1]. In 1

• br Materials and methods br Results

  2020-05-15

  

  Materials and methods Results and discussion Conclusions The fabrication and characterization of AMCs reinforced with SiC and RHA was done in this study. Following conclusions are drawn from the above study: Conflict of interest Authors\' contributions Introduction Industrialisati

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