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br Role of DGAT enzymes in TAG
2020-07-30
Role of DGAT enzymes in TAG metabolism DGAT activity of hepatic microsome preparations has been divided into overt (cytosolic) activity of intact microsomes and latent (luminal) activity that appears following permeablization of microsomes [121]. The latent activity in rat liver microsomes is alm
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br Introduction Cardiovascular disease continues to
2020-07-30
Introduction Cardiovascular disease continues to be the leading cause of death in developed countries. Atherosclerosis, a chronic inflammatory cardiovascular disease, is characterized by the progressive buildup of oxidized low density lipoproteins in the arterial walls (Ross, 1999). In the develo
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Vacuoles are also involved in senescence associated cellular
2020-07-30
Vacuoles are also involved in senescence-associated cellular degradation (Martínez et al., 2008). C13 (legumain-like) cysteine proteases, also called vacuolar processing kinesin inhibitor (VPEs) (Okamoto and Minamikawa, 1995), are involved in many vacuolar proteolytic processes (Diaz and Martinez,
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br Summary Ultimately we may
2020-07-30
Summary Ultimately, we may conclude that CDK inhibitors are ineffective as monotherapy for CLL. This does not preclude their use in this disease, however, as they might instead be employed in either a transient fashion, taking advantage of the tumor lysis phenomenon to eliminate residual (or with
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br Conclusion Further optimization of a azaindole
2020-07-30
Conclusion Further optimization of a 7-azaindole-3-acetic Tianeptine sodium synthesis chemotype derived from HTS delivered a new sub-series of selective CRTh2 receptor antagonists. Exploiting observations from the earlier sulfonamide sub-series, where lipophilicity reduction led to improved eosi
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The CRF receptors are listed in Table A
2020-07-30
The CRF2 receptors are listed in Table 1A and B. The corresponding Class II cytokines are organized by families in Table 2, and are diagrammatically paired with their receptors in Fig. 1. All the receptors except TF appear to function as heterodimers (see below). Although this review will focus on
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From the results of behavioral analysis antagonizing central
2020-07-30
From the results of behavioral analysis, antagonizing central CRF1 receptors seems to be essential to suppress increase in locomotion and anxiety behaviors because Compound B did not reduce locomotion induced by central CRF challenges (Fig. 6B). Compound A decreased locomotion (Fig. 6B) and anxiety
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Another stream of chiller system models
2020-07-30
Another stream of chiller system models focused on FDD. Yan et al. (2018) used a back-tracing sequential forward feature selection algorithm to select the most significant features for FDD and then used the support vector machine for measuring accuracy. Li and Hu (2018) considered the density-based
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Fmoc-Ser-OH In addition there are also a few researches abou
2020-07-30
In addition, there are also a few researches about applying dedication processes into COTS SW. Kim et al. (2000) proposed a COTS SW dedication process based on NUREG/CR-6421 and used methods of TR-106439 to apply SQA identification. However, it does not mention about indirect SW and uses the method
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Following Duncan as a ritualized site
2020-07-30
Following Duncan (1995), as a ritualized site Tyne Cot provides an opportunity for individual tourists to conduct their own acts of remembrance (Edensor, 2000, Iles, 2006). The analysis has also shown that individual acts of writing particular words and phrases in the visitor books are socially shar
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Hence what is proposed here is a technique
2020-07-30
Hence, what is proposed here is a technique highly used in reliability engineering: Software Rejuvenation[4], [21], a technique of proactive fault tolerance in which the system is periodically reboot to clean the memory. In fact, it is well known that most critical SW failures are transient. These m
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In this study CK C
2020-07-30
In this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation a
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Bialaphos sodium salt One possible explanation for differenc
2020-07-29
One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul
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Using a probe substrate to
2020-07-29
Using a probe substrate to determine the metabolic activities of cytochrome P450 is used widely in present drug–drug interaction studies. In this study, the effects of morroniside on the activity, mRNA and protein expression of CYP3A were investigated ex vivo by using rat liver microsomes. The effec
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The temporal data for the effect of
2020-07-29
The temporal data for the effect of antisauvagine-30 pretreatment on urocortin 2 (0.1 mg kg −1) evoked changes in mean arterial blood pressure are shown in Fig. 3. The systemic administration of urocortin 2 (0.1 mg kg−1) at 30 min produced a significant reduction in mean arterial blood pressure when
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