• br Acknowledgments br Introduction Social

  2020-08-03

  

  Acknowledgments Introduction Social software applications – such as wikis, weblogs, and social networking sites (SNS) – have recently attracted organizational researchers’ attention (e.g., Kane and Fichman, 2009, Kane et al., 2014a). The impressive growth of public social web sites, like Faceb

• Several genetic loci have been proposed

  2020-08-03

  

  Several genetic loci have been proposed as risk factors for cognitive decline in the elderly population [[4], [5], [6]]. Among them, catechol-O-methyltransferase (COMT) encodes a key enzyme that degrades dopamine, which is deficient in patients with PD. A common polymorphism at codon 158 (Val158Met,

• mineralocorticoid receptor antagonists Alexithymia is relate

  2020-08-03

  

  Alexithymia is related to abnormal emotional processing. Specifically, the difficulty in identifying one’s own emotions partly attributes to deficits in emotion processing (da Silva et al., 2017; Zamariola et al., 2018). When individuals showed deficits in emotional awareness, emotional self-regulat

• Palladium catalyzed reduction of methylenedioxy acetophenone

  2020-08-03

  

  Palladium catalyzed reduction of 3,4-methylenedioxy acetophenone followed by formylation with α,α-dichloromethyl methyl ether resulted in the key intermediate (). Palladium catalyzed reduction of acetophenone was more efficient than the previously reported method using Wolff-Kishner reduction. Re

• A broad array of pumps transporters play

  2020-08-03

  

  A broad array of pumps/transporters play active role in this ionic disturbance. Some well-characterized pumps include the lactate transporter, monocarboxylate transporter, H+-ATPase, Na+/H+ exchanger etc. (Kato et al., 2013). These fluctuations in pH have far-flung consequences in the body. Tumors

• Acute lung injury ALI is a life threatening disease characte

  2020-07-31

  

  Acute lung injury (ALI) is a life-threatening disease characterized by serious lung inflammation and increased capillary permeability. Isofraxidin (IF) 36, a Coumarin Pergolide mesylate isolated from the natural medicinal plants such as Sarcandra glabra and Acanthopanax senticosus, which have been

• Our results demonstrated that ET a Wnt ligand stimulated

  2020-07-31

  

  Our results demonstrated that ET-1, a Wnt ligand, stimulated the Wnt/β-catenin signaling pathway. First, ET-1/ETRA binds to Frizzled family cell-surface receptors, resulting in the activation of Dvl1, a Dishevelled (DSH) family protein. Next, activated DSH inhibits the Axin, GSK-3β, and APC protein

• br ILCs as chemosensory cells The Aryl

  2020-07-31

  

  ILCs as chemosensory cells The Aryl Hydrocarbon Receptor (AHR) is a ligand-activated TF that binds indoles derived from the bacterial degradation of dietary tryptophan, as well as tryptophan metabolites contained in vegetables [79], bacterial toxins [] and environmental polycyclic hydrocarbons (F

• comt inhibitor E substrate interactions may be constitutive

  2020-07-31

  

  E3-substrate interactions may be constitutive, and, in such cases, regulation can occur at the level of E3 transcription or degradation. The complexity of such trans-regulation is illustrated by the interplay of SCF and APC/C E3s during the cell cycle where, for example, APC/CCdh1 targets the F-box

• br Experimental Procedures br Results br

  2020-07-31

  

  Experimental Procedures Results Discussion Studies of radioactive neurotransmitter release in BMS 753 slices have shown to be useful to estimate the effect of dopamine agonists and antagonists on the presynaptic receptors modulating neurotransmitter transmitter release, as well as their mec

• In this study using REMD with the crystal environment

  2020-07-31

  

  In this study, using REMD with the crystal environment, we investigate the effect of cryo-cooling on the crystal structure of Escherichia coli DHFR. DHFR is an important model enzyme (for review, see, e.g., (30)), and has been studied for decades (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43).

• Dietary triglycerides are hydrolyzed in the small intestine

  2020-07-31

  

  Dietary triglycerides are hydrolyzed in the small intestine by pancreatic lipase to monoacylglycerol and fatty acids, which are then absorbed by the enterocytes and recombined into triglycerides by a series of sequential esterification steps, the final of which is catalyzed by acyl CoA:diacylglycero

• For the first time we provide evidence for COMT

  2020-07-31

  

  For the first time, we provide evidence for COMT Val158Met modulation of long-term fear extinction in humans, evident both in cortical (LPP) and autonomic (fear bradycardia) components of the conditioned fear response. We further found that the initial acquisition of fear is related to dispositional

• As previously described Leu is able to specifically activate

  2020-07-30

  

  As previously described, Leu is able to specifically activate the complex 1 of the mammalian target of rapamycin (mTORC1) (Tato et al., 2011). mTOR pathway is activated as a response to hormonal stimuli (insulin), growth factors (IGF-1) or nutrients (glucose and amino acids). On the other hand, this

• AG-490 A range of inhibitors were therefore

  2020-07-30

  

  A range of inhibitors were therefore synthesized containing either carboxylic AG-490 or ester functionality at the ‘tail’ group as well as variations in the ‘head.’ These were assayed in vitro using the DCIP assay for binding affinity against and human DHODH at 50μM, respectively (). Analysis of

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