• br Materials and Methods br Results

  2021-10-06

  

  Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTAnastrozole mg was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression for

• br Acknowledgments br Free fatty acids

  2021-10-06

  

  Acknowledgments Free fatty acids (FFAs) are not only essential nutritional components, but they also function as signaling molecules. Recently, a G protein-coupled receptor (GPCR) de-orphanizing strategy successfully identified multiple receptors for FFAs, which function on the cell surface and

• The presented results speak for the direct

  2021-10-06

  

  The presented results speak for the direct effects of ghrelin on rat spermatozoa, which are accomplished by the activation of the GHSR-1a receptor. Thus, the results seem to be of physiological significance in vivo since ghrelin, the natural ligand of GHSR-1a, was found to be present in the seminal

• br Experimental br Results and discussion br Conclusion In c

  2021-10-06

  

  Experimental Results and discussion Conclusion In conclusion, four bisnaphthalimides have been investigated for their potential G-quadruplex binding. The compounds 3a, 3b and 5b display high affinity for telomeric and oncogenic G-quadruplexes. On the other hand, 5a only show high affinity f

• Additionally to their peripheral effects evidence indicate a

  2021-10-03

  

  Additionally to their peripheral effects, evidence indicate a role for ETs in the central nervous system (Mosqueda-Garcı́a et al., 1993). Indeed, using Northern blot analysis and in situ hybridization it has been shown the presence of immunoreactive ET of non-vascular origin and of neuronal location

• While reduced protein synthesis provides a model

  2021-10-03

  

  While reduced protein synthesis provides a model to explain the long-term memory defects of kdm5 and kdm5 flies, new translation is not required for short-term memories. The chronic reduction in translation observed in mutant fly strains may, however, lower the levels of proteins necessary for short

• PDEs block GUCY C associated

  2021-10-03

  

  PDEs block GUCY2C-associated second messenger signaling by degrading cyclic nucleotides, whereas inhibition of PDEs activity prevents cyclic nucleotide degradation (Fig. 1). Several researchers have described the pathophysiological roles of various PDEs in numerous tumor cell types, including CRC o-

• Several studies have sought a cross relationship between

  2021-10-02

  

  Several studies have sought a cross-relationship between commensal bacteria-derived metabolites and the Gprs (Blad et al., 2012). Gpr81 is expressed primarily in adipocytes, and hence, lactate-Gpr81 interaction inhibits lipolysis (Cai et al., 2008, Liu et al., 2009). Lactate reduced inflammation by

• ic propranolol The effect of GC on Fgf was not

  2021-10-01

  

  The effect of GC on Fgf21 was not directly dependent on ileal Fgf15 because basal Fgf21 ic propranolol was similar in Fgf15+/+ and Fgf15−/− mice. Moreover, GC treatment induced similar Fgf21 up-regulation in both strains. Fxr activation has been reported to increase Fgf21 expression and secretion [

• We detected the FFAR protein with a

  2021-10-01

  

  We detected the FFAR2 protein with a molecular mass of about 50 kDa, which is comparable to the main band detected in pigs (Li et al., 2014) but different from the calculated size based on the sequence (Wang et al., 2009). The size difference can be explained, at least in part, by glycosylation site

• br Materials and methods br Results

  2021-10-01

  

  Materials and methods Results To examine the apoptosis in FLS in vitro, we measured the number of PNU-120596 in early apoptosis (Annexin V+, 7-AAD−) and late apoptosis/necrosis (Annexin V+, 7-AAD+) using flow cytometry after incubation with or without stimulating Fas antibody. In the absence

• br Cellular transportation of nanoparticles and nanocomplexe

  2021-10-01

  

  Cellular transportation of nanoparticles and nanocomplexes Endocytosis and exocytosis are critically important phenomena in cellular metabolism, which involve the complex vesicular system. They deal with major cellular transportation activities including membrane homeostasis by transporting prote

• very OS has a key role in

  2021-10-01

  

  OS has a key role in the pathogenesis of micro- and macrovascular diabetic complications [3]. There is now convincing evidence that the enzymes that generate ROS and gasotransmitters, such as nitric oxide (NO) and CO, are redox regulated at both the transcription and activity levels, and are also im

• In the present study we conducted

  2021-10-01

  

  In the present study, we conducted a search for other possible endogenous ligands for GPR35. We focused on lysophospholipids because of the homology (30%) between GPR35 and GPR55 whose endogenous ligand is lysophosphatidylinositol (LPI) [9], especially 2-arachidonoyl LPI [10]. Notably, the GPR35 gen

• More recently several groups have characterized a role

  2021-10-01

  

  More recently, several groups have characterized a role for GPR120 signaling via omega-3 fatty acids in amelioration of alcoholic hepatic injury and non-alcoholic fatty liver disease (NAFLD) [18], [19]. Nakamoto et al. demonstrated protective effects of the omega-3 fatty NU 9056 docosahexaenoic aci

14278 records 550/952 page Previous Next First page 上5页 546547548549550 下5页 Last page