• In conclusion we demonstrated that the atypical high basal

  2021-09-16

  

  In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 N,N-Dimethylsphingosine results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network a

• br Materials and methods br Results br

  2021-09-16

  

  Materials and methods Results Discussion The previous studies have reported that positive GLUT1 expression had a predictive value for prognosis of lung cancer patients (Younes et al. 1997a; Meijer et al., 2012; Sasaki et al., 2012). Our conclusion was accordant with these studies. Recently,

• Administration of a fructose rich

  2021-09-16

  

  Administration of a fructose-rich diet to normal rats induces insulin resistance and impaired glucose tolerance or diabetes, depending on treatment duration [23]. We have shown that development of these abnormalities as well as fat deposit in liver, are effectively prevented by co-administration of

• Diperodon HCl receptor The role of the ER EK

  2021-09-16

  

  The role of the ER22/23EK variant which is associated with relative resistance to GC, as shown by a reduction of transactivating capacity in vitro and less suppression of Diperodon HCl receptor levels after 1mg DST in vivo. Relative GC resistance associated with the ER22/23EK polymorphism might prot

• br Acknowledgements br Introduction Ghrelin

  2021-09-16

  

  Acknowledgements Introduction Ghrelin is a potent orexigenic hormone and growth hormone secretagogue mainly derived from the stomach [1], [2], [3], [4], [5]. Other pleiotropic actions of the hormone include those that are glucoregulatory, food reward-enhancing, gastric motility-enhancing, and

• Gap junction intercellular communication GJIC facilitates th

  2021-09-15

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between 133 2 through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depends, at lea

• Several other assay parameters were also explored First the

  2021-09-15

  

  Several other assay parameters were also explored. First, the thermal dependence of the assay was investigated by measuring the specific activity at different temperatures (Fig. 7). That data show that enzymatic activity increases with increasing temperature. Interestingly, the observed rate increas

• Mitochondrial binding by HK prevents mortality

  2021-09-15

  

  Mitochondrial binding by HK prevents mortality by inhibiting pro-apoptotic factor (Bcl-2 family)-mediated opening of the mitochondrial permeability transition pore (mPTP) (Arora and Pedersen, 1988, Calmettes et al., 2016, Kodde et al., 2007, Pedersen et al., 2002, Rosano, 2011, Schindler and Foley,

• Oltipraz has been shown to

  2021-09-15

  

  Oltipraz has been shown to inhibit the growth of HCC ret proto oncogene and is being evaluated in clinical trials as a potential anti-cancer drug for HCC (Mann et al., 2009; Piton et al., 2005; Yates and Kensler, 2007). The present observation that pre-treatment of tumorigenic liver cells with olti

• One of the possibilities of HO

  2021-09-15

  

  One of the possibilities of HO-1 targeting is gene therapy. So far, the majority of preclinical studies have focused on recombinant adeno-associated viral (rAAV) vectors as DNA carriers. They not only provide stable, long-term transgene expression in non-dividing conotoxin mg but also have very lim

• br Financial support This study was

  2021-09-15

  

  Financial support This study was supported by Grant PH-102-PP-11, PH-103-PP-11 from the National Health Research Institutes, Taiwan. Conflict of interest Please refer to the accompanying ICMJE disclosure forms for further details. Authors’ contributions Acknowledgements Introduction

• In human platelets only and

  2021-09-15

  

  In human platelets, only α1 and β1 isoforms of sGC are expressed in equimolar concentrations (3700 copies for β1, and 3500 copies for α1 per platelet) [57] [62]. sGC, is usually a heterodimer and contains heme as cofactor which is required for high-affinity NO binding and stimulation of its activity

• mt t Recently it was found that hypoxia results

  2021-09-15

  

  Recently, it was found that hypoxia results in the phosphorylation of β-catenin at Y654 in a Src-dependent manner (Xi et al., 2013). All β-catenin phosphorylated at this residue was found complexed with Hif1α and it was demonstrated that this β-catenin phosphorylation was required for Src to promote

• To characterize the basic functions of GPR in phagocytes we

  2021-09-15

  

  To characterize the basic functions of GPR84 in phagocytes, we have utilized the receptor selective antagonist GLPG1205 (a small selective antagonist of GPR84 developed by Galapagos NV [14]) together with ZQ16 (2-(hexylthio) pyrimidine-4,6-diol), a potent GPR84 selective agonist identified in a high

• Likewise and considering the aforementioned biological actio

  2021-09-15

  

  Likewise, and considering the aforementioned biological actions of ketogenic diet-derived MCFA on neuronal excitability, it could be postulated that specific receptors for fatty acids could also be involved. For example, the GPCR for medium to long chain fatty acids, FFA1/GPR40, might also contribut

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