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A comparison of our results with
2021-12-09
A comparison of our results with literature data on the action of pregnane and androstane steroids on the functional activity of NMDAR, GABAAR and GlyR enables us to draw the following conclusions. First, androstane steroids (with no substituents at C-17) at a concentration up to 50 μM do not affect
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Developmental studies have reported that some subunits of
2021-12-09
Developmental studies have reported that some subunits of GABAA receptors like α2 and α3 are predominantly expressed during in-utero development, and then substituted for α1 around birth in the rat hippocampus (Brooks-Kayal et al., 2001; Fritschy et al., 1994; Golshani et al., 1997; Kapur and Macdon
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The optimum parameter sets were detected
2021-12-09
The optimum parameter sets were detected by the highest J-statistic for the training set and applied to the test set for evaluation. J-statistics obtained from the test set is reported at Table 2 along with respective parameters. We also applied QP, G4H and PQSF methods, in order to compare the pre
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The improved glucose tolerance of Ffar R W R W
2021-12-09
The improved glucose tolerance of Ffar1R258W/R258W mice on HFD was unexpected. In combination with similar fasting blood glucose levels, the significant lower fasting plasma insulin of mutant mice compared to wild-type mice is indicative of improved insulin sensitivity. However, peripheral insulin r
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Much is known about FPPS structure and
2021-12-09
Much is known about FPPS structure and function, with over 120 FPPS crystal structures being currently available. This wealth of information is largely the consequence of human FPPS serving as a drug target for the treatment and/or prevention of pathologies such as osteoporosis, hypercalcemia and Pa
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In summary our results support
2021-12-09
In summary, our results support the model that the histone demethylase KDM5 is a critical host transcriptional regulator that maintains immune homeostasis and is responsible for preservation of the normal commensal microbial community structure and behavior. Neurodevelopmental disorders such as ID a
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ANT located in the IMM mediates
2021-12-08
ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions
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br Conclusion and future perspectives In the setting of
2021-12-08
Conclusion and future perspectives In the setting of myocardial I/R stress, HDAC activity is induced and contributes to myocardial injury. HDAC inhibition appears to protect the TG003 from I/R injury by activating a variety of pro-survival molecular pathways. From a clinical relevance standpoint,
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br Methods br Results br Discussion Peptide therapeutics rep
2021-12-08
Methods Results Discussion Peptide therapeutics represents a unique class of biopharmaceuticals that continues to evolve in drug discovery and development. We and others have been particularly interested in bioengineering innovative pGC-A and/or pGC-B peptide activators. This has been succe
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The diversity of biological properties and interactions of
2021-12-08
The 3230 mg of biological properties and interactions of GSK-3 have been reviewed recently (, , , , ). The interactions of GSK-3 in the signaling pathways induced by nutraceuticals is covered in the review by ) in this special issue of . GSK-3 is a frequent target of many nutraceuticals such as cur
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topotecan While PLGA implants could be beneficial for regene
2021-12-08
While PLGA implants could be beneficial for regenerative angiogenesis in the context of wound healing, they topotecan could also lead to adverse effects. Indeed, extracellular acidification inhibits osteoblast proliferation, differentiation, and extracellular matrix mineralization, which might hamp
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br Methods br Results br Discussion LPD in terms
2021-12-08
Methods Results Discussion LPD, in terms of insufficient secretion of progesterone by the CL, reflected by low serum progesterone levels can occur in IVF attempts using any kind of ovarian stimulation protocol (Fatemi et al., 2007, Garcia et al., 1981, Van der Linden et al., 2011). However,
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apexbio molarity br Introduction The generic antifibrinolyti
2021-12-08
Introduction The generic antifibrinolytic drug tranexamic apexbio molarity (TXA) inhibits the protein-protein interaction between plasminogen and fibrin [9]. TXA is frequently used to reduce bleeding in various hemorrhagic conditions, such as during surgical procedures in the heart [19]. However
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Histamine functions as a key neurotransmitter in multiple ci
2021-12-08
Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, Cap Firefly Luciferase mRNA is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine
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Therefore we investigated the acute and
2021-12-08
Therefore, we investigated the acute and delayed response of 92 human mono- and dizygous twins to an acute shift from low fat to high fat diet with respect to serum levels of VEGF and the expression of SLC2A1 in subcutaneous adipose tissue (AT). By comparing the degree of concordance of basal and di
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