• In teleosts GR is expressed in

  2021-12-23

  

  In teleosts, GR is expressed in almost every cell and regulates genes controlling development, metabolism, and immune response [17,18]. Several teleosts contain two GR genes, GR1 and GR2 [8]. Other groups have found only one GR in some species thus far, such as the Japanese flounder, brown trout, an

• Besides its established insulinotropic actions GIP has been

  2021-12-23

  

  Besides its established insulinotropic actions, GIP has been shown to possess other direct beneficial effects on the beta cell, including stimulation of growth, differentiation, proliferation and survival.21, 22, 23 It has also been shown to stimulate proinsulin gene transcription and translation. M

• biotin-LC-LC-tyramide sale br Secretase modulators a loss of

  2021-12-23

  

  γ-Secretase modulators: a loss of pharmacology? A lack of translation from in vitro to in vivo pharmacology is an unresolved issue among most GSMs. R-flurbiprofen was tested in clinical trials, however, it did not achieve statistical significance on either of its primary endpoints – cognition or

• br Conclusions br Acknowledgments This study was supported b

  2021-12-23

  

  Conclusions Acknowledgments This study was supported by funds from the National Natural Science Foundation of China (NSFC 31360245, 31460258) and the Applied Basic Research Foundation of Yunnan Province of China (2011FZ111). Introduction Acute myocardial infarction is the undoubted cause o

• Ionotropic aminobutyric acid GABA receptors

  2021-12-23

  

  Ionotropic γ-aminobutyric Adenosine 5-monophosphate australia (GABA) receptors (GABARs) belong to the Cys-loop ligand-gated ion channel (LGIC) superfamily and play an important role in the rapid inhibitory synaptic transmission in nervous systems of both vertebrate and invertebrate (Buckingham et a

• In a follow up study the same research group

  2021-12-22

  

  In a follow up study, the same research group further characterized FFA4 involvement in DU145 and PC-3 cancer cell lines by demonstrating that the anti-proliferative and anti-migration activities of FFA4 require the presence of LPA1 receptor (LPA1R), suggesting a mechanism consistent with negative c

• br Role of FPRs in Cancer br

  2021-12-22

  

  Role of FPRs in Cancer Concluding Remarks Activation of FPRs by formylated bacterial peptides or by host-derived mitochondrial peptides is required for local control of infection and wound healing. Nevertheless, various detrimental effects can result from the release of formylated peptides int

• Immunohistochemistry using anti FFAR antibodies

  2021-12-22

  

  Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import

• The cytotoxicity of these compounds against Hep

  2021-12-22

  

  The cytotoxicity of these compounds against Hep3B cells was assessed using the MTT assay. As shown in , compounds in series and (except ), which retained the carboxyl at C-17, showed no appreciable cytotoxic activity (IC > 100 μM), whereas compounds in series (except ,) were modestly cytotoxic, i

• CL-387785 One of the possibilities of HO targeting is gene t

  2021-12-22

  

  One of the possibilities of HO-1 targeting is gene therapy. So far, the majority of preclinical studies have focused on recombinant adeno-associated viral (rAAV) vectors as DNA carriers. They not only provide stable, long-term transgene expression in non-dividing CL-387785 but also have very limite

• Due to the importance of gene regulation in cancers

  2021-12-22

  

  Due to the importance of gene regulation in cancers, HDAC inhibitors have been studied extensively in cancer biology and are in current clinical use as anti-tumor therapies [17]. The HDAC inhibitors vorinostat, romidepsin, and belinostat have been approved for certain T-cell lymphomas, and panobinos

• br FFA GPR was deorphanised as the second

  2021-12-22

  

  FFA4 GPR120 was deorphanised as the second receptor for long-chain fatty acids in 2005 [5]. Initial focus highlighted expression in the lower gut, the capacity of unsaturated fatty acids to promote release of the incretin glucagon-like peptide-1 (GLP-1) from the enteroendocrine cell line STC-1, a

• One clue to how evolution has solved such spatiotemporal cha

  2021-12-22

  

  One clue to how evolution has solved such spatiotemporal challenges comes from studies revealing that lymph node (LN) organization is more complex than originally presumed, suggesting that steady-state microanatomical features are crucial for effective immune responses (reviewed by Qi et al., 2014).

• Flaviviruses consist of a nucleocapsid composed

  2021-12-22

  

  Flaviviruses consist of a nucleocapsid, composed of multiple copies of the capsid protein (C) and the single-stranded, positive-sense RNA genome. The nucleocapsid is surrounded by a lipid bilayer in which two transmembrane proteins are inserted, the envelope glycoprotein E and the membrane protein M

• Introduction Substantial body of evidence supports the notio

  2021-12-22

  

  Introduction Substantial body of evidence supports the notion that GABA, the dominant inhibitory neurotransmitter in the hypothalamus of mammals, affects GnRH release by two classes of membrane receptors: GABAA (GABAAR) [1] and GABAB (GABAB R) [2]. Studies in rodents and sheep have documented that

14279 records 498/952 page Previous Next First page 上5页 496497498499500 下5页 Last page