• The diseases of ocular surface and the cornea

  2021-11-22

  

  The diseases of ocular surface and the cornea are very common in ophthalmological practice and as a result there is a continuous, need for novel therapeutic options. Here, we demonstrated a corneal distribution of GPR35, a potential molecular target for new drugs (; ). The search for the expression

• Fig summarizes the underlying mechanism

  2021-11-22

  

  Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid

• br Materials and methods br

  2021-11-22

  

  Materials and methods Acknowledgements The following reagents were obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: SIVagm155-4 from Dr. Vanessa Hirsch and Dr. Philip Johnson; Anti-SIVmac251 Polyclonal; SIVagm tan-1 infectious molecular 69 9 receptor from Drs. Marc

• Rapid action of E on GnRH neurons has been known

  2021-11-22

  

  Rapid action of E2 on GnRH neurons has been known for some time. E2 hyperpolarizes guinea pig GnRH neurons, alters cAMP production in GT1-cells and stimulates or inhibits [Ca2+]i oscillations within 15 min (Lagrange et al., 1995; Navarro et al., 2003; Temple et al., 2004; Romanò et al., 2008). Impor

• br Transporter based brain targeting nano

  2021-11-22

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the selective serotonin reuptake inhibitor from harmful substances. Since only selected,

• The lactam compounds including ceftriaxone CEF have shown to

  2021-11-22

  

  The β-lactam compounds, including ceftriaxone (CEF), have shown to attenuate drug-seeking in several drugs of abuse including methamphetamine [31], cocaine [32,33], nicotine [34] and morphine [35]. Moreover, in our laboratory, we have shown that CEF can reduce chronic alcohol drinking via upregulati

• The discovery that GLUT in

  2021-11-22

  

  The discovery that GLUT1 in the microvasculature represents an important target of VEGF thereby affecting POM 1 receptor function is highly relevant. The work of Jais et al. identified VEGF as a determining player in the regulation of cognitive performance and provides an important link to the unfav

• Transient forebrain ischemia in rodents

  2021-11-22

  

  Transient forebrain ischemia in rodents induces a reduction in expression of mRNA encoding the AMPA receptor subunit GluR265, 66, 67, 68, 69 (Fig. 3). gluR2 mRNA expression is markedly reduced in the CA1 region (the Radicicol region most vulnerable to ischemia-induced damage), but not in the CA3 re

• The role of GJs in liver

  2021-11-22

  

  The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po

• Galanin a amino acid peptide was first isolated

  2021-11-22

  

  Galanin, a 29/30-amino-acid peptide, was first isolated in 1983 from porcine intestine by Tatemoto and collaborators [70]. It is widely distributed throughout the central and peripheral nervous systems as well as other tissues. It is involved in a wide range of physiological functions, such as modul

• Bile acids BAs are critical for facilitating

  2021-11-22

  

  Bile acids (BAs) are critical for facilitating the AG-120 of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, and vitamin D rece

• Mevastatin It should be noted that the current studies were

  2021-11-20

  

  It should be noted that the current studies were performed in female rats. Although the oestrous cycle has been shown to modulate inflammatory processes in the periphery, data from our group has demonstrated that the phase of the oestrus cycle does not significantly alter TLR3-mediated neuroinflamma

• Thus from this preliminary study a working

  2021-11-20

  

  Thus from this preliminary study, a working model of HIV-1 integrase was developed from which a selective inhibitor of the strand-transfer reaction displaying whole-cell activity and negligible cytotoxicity was produced. Compound 9 provides a promising scaffold for further elaboration, and current i

• br S proteins and HBV induced autophagy HBV surface proteins

  2021-11-20

  

  S proteins and HBV-induced autophagy HBV surface proteins (S proteins or HBs) are reported to trigger HBV-induced autophagy by inducing ER stress and UPR in host 4sc [22]. HBx and HBV-induced autophagy HBx is a multifunctional viral protein. It can regulate virus replication, promote cell li

• PLP has been found to

  2021-11-20

  

  PLP has been found to be effective inhibitor of many enzymes that have GW311616 hydrochloride synthesis for phosphate-containing substrates or effectors, including RNA polymerase [14], [15], reverse transcriptase [16], and DNA polymerase [17], [18]. Oka et al. [19], [20] reported that vitamin B6 de

13921 records 494/929 page Previous Next First page 上5页 491492493494495 下5页 Last page