• The mD plasmid containing CD domain gene

  2022-02-23

  

  The mD1.2 plasmid containing CD4 domain 1 gene under the control of a promoter was obtained as a gift from Dr. Dimiter S. Dimitrov. The mD1.2 plasmid was digested using restriction endonuclease I (New England BioLabs, USA) to release the mD1.2 gene. The gene encoding the mD1.2 protein was elongated

• Although both receptors mGluR and mGluR are present in corti

  2022-02-23

  

  Although both receptors, mGluR1 and mGluR5, are present in cortical and hippocampal areas from 1 to 2 weeks old neonates (López-Bendito et al., 2002) we have found that only mGluR1 was regulated after maternal l-Glu consumption. A possible explanation could be based on the different ontogenetic prof

• SIS3 Instead our results reveal that autophagy controls the

  2022-02-23

  

  Instead, our results reveal that autophagy controls the membrane association of the cargo-selective SNX-BAR retromer assembly (comprised of the VPS35/29/26 trimer in association with SNX1/2 and SNX5/6), which has been demonstrated to promote GLUT1 surface recycling. Accordingly, GLUT1 localization i

• GCK MODY is the most common form

  2022-02-23

  

  GCK-MODY is the most common form of MODY diabetes in many populations (Chevre et al., 1998; Massa et al., 2001; Barrio et al., 2002; Estalella et al., 2007; Pruhova et al., 2010; Capuano et al., 2012; Giuffrida et al., 2017). However, data about GCK-MODY among North African populations are very rar

• It was previously proposed that glucagon acts

  2022-02-23

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the e mycin via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the liver bu

• Besides its established insulinotropic actions GIP has been

  2022-02-23

  

  Besides its established insulinotropic actions, GIP has been shown to possess other direct beneficial effects on the beta cell, including stimulation of growth, differentiation, proliferation and survival.21, 22, 23 It has also been shown to stimulate proinsulin gene transcription and translation. M

• Fibroblast growth factor receptors FGFRs play an

  2022-02-23

  

  Fibroblast growth factor receptors (FGFRs) play an essential role in the regulation of cell survival, proliferation, migration and differentiation. FGFRs are a family of receptor tyrosine kinases (RTKs) exhibiting an extracellular immunoglobulin (Ig)-like ligand binding domain, a transmembrane domai

• In addition to removing proteins and organelles related

  2022-02-23

  

  In addition to removing proteins and organelles related to iron and lipid metabolism, an alternative mechanism by which autophagy promotes ferroptosis is through the formation of the BECN1-solute carrier family 7 member 11 (SLC7A11) complex [42,43]. SLC7A11 is the main component of the antiporter sy

• br Acknowledgements br Introduction Muscle FBPase is very se

  2022-02-23

  

  Acknowledgements Introduction Muscle FBPase is very sensitive to AMP inhibition and in the presence of physiological concentrations of this effector in muscle fibres FBPase should be almost completely inactive [1], [2]. Recently, we have presented evidence that, in vitro, muscle aldolase binds

• Here we showed that microinjection of siRNA at the MII

  2022-02-23

  

  Here we showed that microinjection of siRNA at the MII stage efficiently reduced endogenous EZH2 mRNA and protein. Although the percentage of cleaving embryos was not affected, Ion Channel Compound Library formation and blastocyst cell number were both reduced in EZH2 knockdown groups (Table 1). Sim

• Compounds and were evaluated for

  2022-02-23

  

  Compounds and were evaluated for their pharmacokinetic properties in rats and the results are summarized in . Following intravenous (IV) administration, both compounds displayed low clearance (CL), short half-lives (t) and low volumes of distribution (V). When dosed orally as a solution, exposure

• There are limited studies on antibody responses

  2022-02-23

  

  There are limited studies on antibody responses against HIV-1 integrase antigen. According to previous studies, almost 5 percent of individuals infected with HIV never raise anti-integrase T-5224 (Rikhtegaran Tehrani et al., 2015; Chang et al., 1985). If this rate is identical in individuals infect

• br H R agonists In search for potent

  2022-02-23

  

  H2R agonists In search for potent and selective H2R agonists, comprehensive structure–activity relationship studies have been conducted and led to the first H2R agonists, e.g. 4(5)-methylhistamine (16) which is actually now used as selective H4R agonist (Fig. 4) (Durant et al., 1975, Lim et al.,

• straight from the source YAP TAZ nuclear function is also in

  2022-02-22

  

  YAP/TAZ nuclear function is also influenced by interaction with the TEAD family of transcription factors [96, 97, 98, 99, 100, 101]. The RAC1 straight from the source exchange factor protein TIAM1 has recently been linked to YAP/TAZ regulation in the nucleus and cytoplasm. Nuclear TIAM1 inhibits YA

• Tanshinone IIA---sulfonic sodium In order to estimate the in

  2022-02-22

  

  In order to estimate the influence of mitochondrial hypo-polarization on generated OMP, IMP was changed from the normal value of Δψi = −140 mV (Fig. 4A, D, G) to Δψi = −100 mV (Fig. 4B, E, H), resulting in lower magnitudes of calculated OMP for hypo-polarized Tanshinone IIA---sulfonic sodium (Fig.

13927 records 440/929 page Previous Next First page 上5页 436437438439440 下5页 Last page